The Acute Inhalation Toxicity of Pyrolysis Products of Halon 1301: Exercise Potentiation of Expression of Lung Injury Induced by Compounds 1 and 2
Final rept. 1 Apr 1987-30 Sep 1990
LOS ALAMOS NATIONAL LAB NM
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This final report summarizes investigations that have focused on the lower respiratory tract toxicities of inhaled perfluoroisobutylene PFIB compound 1 and bistrifluoromethyldisulfide TFDCompound 2, and it describes how the injurious effects of these compounds may be enhanced by post-exposure exercise andor result in a reduction in work performance capacity. The major objectives of the project were 1to determine if the expression of lung injury induced by PFIB and TFD can be increased in severity by post-exposure exercise using lung gravimetric and histopathologic criteria as endpoints, and to characterize the post-exposure period of time during which the expression of PFIB- and TFD-induced lung injury can be potentiated by exercise, i.e., the window of susceptibility.
- Medicine and Medical Research