Pyridostigmine and Warm Water Diving Protocol 90-05. 1. Protocol and General Results
Technical rept. Sep-Oct 1990
NAVAL MEDICAL RESEARCH INST BETHESDA MD
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A study was conducted to determine whether pre-treatment with pyridostigmine affected performance of divers in warm water. This report contains a review of pyridostigmine effects, experimental design, and general results obtained from the study. Ten U.S. Navy divers performed two 7-hour warm airwater test exposures. Each test consisted of a 4-hour pre-dive exposure to 37.8 C100 F air at the surface, followed by a 3-hour dive in 34.4 C 94 F water at a depth of 20 fsw 1.6 ATA breathing 100 O2. Subjects performed light-moderate leg exercise during the immersion phase. During the first 2 h of immersion subjects exercised in a pattern of 30 min work and 10 min rest. During the last hour subjects exercised in a pattern of 5 min light work, 10 min moderate work and 5 min rest. Tests were conducted in a balanced order once after the subjects ingested pyridostigmine one 30 mg tablet every 8 h for two days prior to testing and once after ingesting placebo tablets over the same time periods.
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