Interferon Inducers against Infectious Diseases
Annual rept. 23 Mar 1989-13 Jun 1990
ROSWELL PARK MEMORIAL INST BUFFALO NY
Pagination or Media Count:
A series of interferon inducers was developed, in which carboxymethyl cellulose the undesired component of poly ICLC was replaced by other anionic polymers or by graft polymers of polyL-lysine with saccharides. Most of these showed effective antiviral action against Rift Valley Fever virus and Punta Toro virus. Most were less toxic than poly ICLC and were non-immunogenic. The promising replacements for carboxymethylcellulose are carboxymethylamylose, carboxymethyl Beta cyclodextrin, gelatin, sulfated gelatin, sulfated Beta cyclodextrin, polylysine-dextran graft, and polylysine-glucose graft.