Accession Number:

ADA230483

Title:

Conditioned Taste Aversion and Cholinergic Drugs: Pharmacological Antagonism

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1987-01-01

Pagination or Media Count:

6.0

Abstract:

The effectiveness of drugs as unconditioned stimuli UCSs in the conditioned taste aversion CTA procedure may be influenced by specific pharmacological antagonism. The present studies examined the UCS effects of two carbamates, physostigmine salicylate PS and pyridostigmine bromide PB, and three anticholinergic compounds, atropine methyl nitrate AMN, atropine sulfate AS, and benactyzine hydrochloride BH. Individual drugs, as well as combinations of the carbamates and the anticholinergics, were studied in a two- bottle procedure in rats. The lowest effective doses for eliciting significant CTAs were PS, 0.32 mgkg PB, 1,00 mgkg AMN, 0.04 mgkg AS, 0.07 mgkg and BH, 0.90 mgkg, IP. Combinations of PS with either AMN or BH were mutually antagonistic as UCSs, whereas PS with AS was not. PB with AMN, but not with AS, also showed antagonism in the procedure. The present results suggest that the CTA procedure is well-suited for direct examination of cholinergic drug effects and may also be used to explore interactions of different classes of cholinergic drugs. js

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE