Persistently Low Natural Killer Cell Activity and Circulating Levels of Plasma Beta Endorphin: Risk Factors for Infectious Disease
PITTSBURGH UNIV PA SCHOOL OF MEDICINE
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Beta endorphin levels were quantitated in plasma samples obtained from normal subjects n81, 37 males and 63 females, age range 18-45 years as a component of a prospective study examining the relationship of illness morbidity to natural killer cell activity and psychological indices of stress. The present study was designed to test whether beta endorphin levels contributed additionally to the explanation of illness outcome variance. In the larger study, persistently low NK LNK activity was associated prospectively with higher illness morbidity. The findings reported here suggest that the observed LNK activity might be affected by circulating levels of plasma beta endorphin, as lower endorphin levels predicted the LNK pattern, which in turn predicted higher illness morbidity.
- Medicine and Medical Research