Accession Number:

ADA230203

Title:

Bridged Bicyclic Systems and Pretreatment Drugs as Acetylcholinesterase Reactivators

Descriptive Note:

Annual rept. 15 Jul 1986-14 Jul 1987

Corporate Author:

ILLINOIS UNIV AT CHICAGO CIRCLE DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1989-12-15

Pagination or Media Count:

47.0

Abstract:

During the past year, and - 2-oximinotropan-3-one methiodides have been synthesized as well as the racemic compound 2-oximinotropan-3-one methiodide. The regioisomeric and - 3-oximinotropan-3-one methiodides have also been synthesized. Binding constants to AChE, pKas and reactivation activities for these compounds have been determined. Atropine-like 3-acetophenyl tropine oxime hydrochloride has been synthesized and submitted for testing. Syntheses of 4-1-piperidinyl-4-pheylcyclohexanone oxime methiodide, 1-1- phenylcyclohexyl-4-piperidone oxime methiodide and 2-benzylidene-3- quinuclidinone oxime hydrochloride have been achieved.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE