Bridged Bicyclic Systems and Pretreatment Drugs as Acetylcholinesterase Reactivators
Annual rept. 15 Jul 1986-14 Jul 1987
ILLINOIS UNIV AT CHICAGO CIRCLE DEPT OF CHEMISTRY
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During the past year, and - 2-oximinotropan-3-one methiodides have been synthesized as well as the racemic compound 2-oximinotropan-3-one methiodide. The regioisomeric and - 3-oximinotropan-3-one methiodides have also been synthesized. Binding constants to AChE, pKas and reactivation activities for these compounds have been determined. Atropine-like 3-acetophenyl tropine oxime hydrochloride has been synthesized and submitted for testing. Syntheses of 4-1-piperidinyl-4-pheylcyclohexanone oxime methiodide, 1-1- phenylcyclohexyl-4-piperidone oxime methiodide and 2-benzylidene-3- quinuclidinone oxime hydrochloride have been achieved.
- Medicine and Medical Research