Frontal Decortication and Adaptive Changes in Striatal Cholinergic Neurons: Neuropharmacological and Behavioral Implications
Final rept. 28 Sep 1989-28 Sep 1990
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI MILAN (ITALY)
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Molecular Mechanism studies autoradiographic and saturation binding experiments showed a marked reduction of 3H hemicholinium-33HHCh-3 binding to sodium-dependent high-affinity choline uptake SDHACU sites in striatum two weeks after frontal decortication. Oxiracetam 100 mgkg i.p., a nootropic drug, did not affect the distribution of 3HHCh-3 binding sites in sham-operated rats but completely overcame the reduction in the Bmax of decorticated striatum. This result is consistent with the increase in SDHACU in decorticated striatum after oxiracetam treatment. Frontal decortication did not change the percentage of the mAChR subtypes M1 and M3 present in the striatum and did not affect GppNHp modulation of binding affinity for the muscarinic cholinergic agonist oxotremorine OTMN in the striatum. Frontal decortication did not affect the activation of phosphoinositide turnover PI induced by carbachol but it enhanced the stimulation of PI turnover induced by ibotenic acid, a glutamatergic agonist.
- Medicine and Medical Research