Accession Number:

ADA230062

Title:

An Experimental Brain Missile Wound: Ascertaining Pathophysiology and Evaluating Treatments to Lower Mortality and Morbidity

Descriptive Note:

Annual rept. 14 Apr 1988-13 Apr 1989

Corporate Author:

LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS

Personal Author(s):

• Carey, Michael E.
• Torbati, Dan
• Soblosky, Joweph
• Davidson, June
• Farrell, J. B.

Report Date:

1990-10-26

Pagination or Media Count:

140.0

Abstract:

Chemical regulation of CBF Normoxic hypocapnia PaCO to the second power 21 mmHg significantly reduced total CBF and many rCBFs both before and after wounding but after wounding this response may have been attenuated except around the wound track where CBF reduction was enhanced. Effect of wounding on selected physiologic variables which might account for death. The effect of brain wounding on lung water was insignificant. The effect increased intracranial pressure on brain biogenic amines. The monoaminergic neurotransmitters EPI, NE, 5-HT and some their metabolities DOPAC, HVA, 5-HIAA were evaluated in selected brain stem areas and the hypothalamus after increases in ICP sufficient to elicit an immediate Cushing response.

Descriptors:

• *GUIDED MISSILES
• BRAIN
• CHEMICALS
• WATER
• VARIABLES
• AMINES
• INTERNAL
• PRESSURE
• LUNG
• PHYSIOLOGY
• WOUNDS AND INJURIES
• DEATH
• PATHOPHYSIOLOGY
• MORTALITY RATE
• NEUROTRANSMITTERS
• HYPOTHALAMUS
• SKULL
• CONTROL

Subject Categories:

• Anatomy and Physiology
• Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE