Accession Number:

ADA230042

Title:

Inhibition of T Cell Receptor Expression and Function in Immature CD4+CD8+ Cells by CD4

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

• Nakayama, Toshinori
• June, Carl H.
• Munitz, Terry I.
• Sheard, Michael
• McCarthy, Susan A.

Report Date:

1990-09-28

Pagination or Media Count:

5.0

Abstract:

Most immature CD4CD8 thymocytes express only a small number of T cell receptor TCR molecules on their surface, and the TCR molecules they do express are only marginally capable of transducing intracellular signals. TCR expression and function was not intrinsically low in immature CD4CD8 thymocytes, but was found to be actively inhibited by CD4-mediated signals. Indeed, release of CD4CD8 thymocytes from CD4-mediated signals resulted in significant increases in both TCR expression and signaling function. These results suggest that, in CD4CD8 cells developing in the thymus, increased TCR expression and function requires release from CD4-mediated inhibition.

Descriptors:

• *FUNCTIONS
• MOLECULES
• CELLS
• THYMUS
• INHIBITION
• CELLS(BIOLOGY)
• SENSE ORGANS
• REPRINTS
• SIGNALS

Subject Categories:

• Biochemistry
• Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE