Radioprotection of Intestinal Stem Cells and Whole Body Radiation Lethality from Photons and Neutrons by Prostaglandins along or in Combination with WR-2721
Technical rept. 24 Feb 1986-30 Sep 1989,
RUSH-PRESBYTERIAN-ST LUKE'S MEDICAL CENTER CHICAGO IL
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Prostaglandins PGs have been shown to protect the gastrointestinal and hematopietic cell renewal systems from some degree of radiation damage. The mechanisms to account for these observations are unknown. Based on preliminary evidence that PGs varied in the degree to which they afforded protection of intestinal stem cells, we studied protection by several PGs and their analogues. The most protective PGs found to date were 16,16 dm PGE2, misoprostol, a PGE1 analogues, and iloprost, a PGI2 analogue. The relative degrees of protection were 400, 700 and 800 above control valves at a dose of 13.5 137 Cs gamma radiation. These three PGs were used for subsequent studies. Iloprost is a stable PG at room temperature and was found to be protective given orally. In addition to radioprotection of the intestinal stem cells, these Pgs increased the LD506, LD5030 and animal longevity through both the gastrointestinal and hematopoietic syndromes. Misoprostol protected the gut from JANUS neutrons and increased animal longevity following neutron irradiation. Although the mechanism for PG-induced radioprotection is unknown, it appears to be different compared to the widely studied amino thiol, WR-2721. Evidence to support this contention came from data showing that all these analogues were additive to the protective effect of Wr-2721.
- Nuclear Radiation Shielding, Protection and Safety