Effect of Cholinergic Perturbations on Neuromotor-Cognitive Performance
Annual rept. 1 Aug 1985-31 Jul 1986
DUKE UNIV MEDICAL CENTER DURHAM NC
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Atropine d, 1-hyoscyamine , an antimuscarinic drug, is widely used as an antidote for anticholinesterase poisoning, as pre-operative medication and for the treatment of conditions, such as peptic ulcers and Parkinsonism. A series of studies was designed to examine the pharmacokinetic-pharmacodynamic relationship of atropine for various cognitive and neuromotor tasks and several physiological measures. In the first study which has been completed, single doses of placebo and 0.5, 1.0 and 2.0 mg of atropine were administered intramuscularly during the four test sessions to eight healthy young male volunteers according to a Latin square design balanced for order of dose administration. Keywords Antimuscarinic pharmacokinetic-pharmacodynamic relationship cognitive, Neuromotor, Physiological measures, Stress hormones.