Accession Number:

ADA229594

Title:

Comparison of Endobronchial and Tracheal Insufflation for Acute Respiratory Distress

Descriptive Note:

Midterm rept. 15 Sep 1988-14 Mar 1988

Corporate Author:

MARYLAND UNIV BALTIMORE DEPT OF ANESTHESIOLOGY

Personal Author(s):

Report Date:

1990-03-14

Pagination or Media Count:

77.0

Abstract:

Prototype airway catheters were developed 1 to allow ventilation with a continuous flow of air into the mainstream bronchi EI and 2 to oxygenate by flowing O2 into the trachea TRIO. Minimum flows Vmin using EI and TRIO were 0.2-0.3 Lkgmin air and 90 mlmin O2, respectively. Ventilation for up to 4 hours with Vmin EI was carried out in anesthetized dogs and physiological parameters were measured serially during apnea produced by neuromuscular blockade. Vmin EI was repeated after tetrodotoxin TTX was infused to produce apnea. Ventilation with Vmin TRIO produced oxygenation for over 2 hours in some animals, and all could be returned to normality by conventional ventilation Vmin TRIO after TTX was less successful, but all animals survived at least 40 min before blood pressure dropped below 40 mmHg. High-flow 2Lmin TRIO successfully resuscitated all TTX-poisoned animals and kept them alive for 4 hours. Generous-flow EI 1 Lkgmin was equally successful in TTX-poisoned animals. Keywords Continuous-flow ventilation Endobronchial insufflation Eracheal insufflation of O2 Apnea Tetrodotoxin TTX Organophosphorus poisoning Field ventilation Resuscitation Gas supplies Ventilation Oxygenation.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE