Accession Number:

ADA229411

Title:

Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets

Descriptive Note:

Final rept. 1 Sep 1986-31 Aug 1989,

Corporate Author:

BIRMINGHAM UNIV (UNITED KINGDOM) DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1989-11-01

Pagination or Media Count:

264.0

Abstract:

The work described here is an attempt to synthesis nucleoside analogues which are targetted against the replicase of negative-strand viruses. Two lines of investigation have been attempted i the synthesis of 5-vinyl substituted pyrimidine ribonucleosides and ii the synthesis of potential nucleotide pro-drugs. A series of compounds of type i have been synthesised and submitted for biological evaluation. Strategies for the synthesis of compounds of type ii have been developed but we have not had time to prepare sufficient suitable material for testing purposes. js

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE