Influence of Anticholinesterase on Distribution of Ventilation and Gas Exchange
Final rept. Jan-Nov 1985
VIRGINIA MASON RESEARCH CENTER SEATTLE WA
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This project was designed to titrate the influence of pyridostigmine on pulmonary resistance and gas exchange. Experiments in pigs and dogs indicate that significant alterations in pulmonary function do not occur until acute dosages in the range of 3-6 mgkg are reached. Furthermore, acute administration of large doses of pyridostigmine results in salivation and gastrointestinal stimulation well in advance of any impairment to respiratory function.