Control of Cytokine Gene Expression in Macrophages: Role of Second Messenger Pathways
Annual rept. no. 2
LOYOLA UNIV OF CHICAGO IL
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Several cytokines are produced by IL-2 stimulated PBL and many of these mediators are capable of either directly or indirectly inducing fibroblast proliferation and connective tissue collagen deposition. It has been shown that macrophages, for example, produce several factors for fibroblast, including interleukin-1 IL-1 Schmidt et al, 1982, tumor necrosis factor-alpha platelet derived growth factor, fibroblast growth factor. Two of these cytokines, TG and PDGF are highly fibrogenic. Aberrant production of these mediators in animal models of lung fibrosis have demonstrated that activated macrophages secret cytokines which induce the proliferation of cultured fibroblasts.
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