Accession Number:

ADA229139

Title:

Manual of Hemorrhagic Fever with Renal Syndrome

Descriptive Note:

Corporate Author:

KOREA UNIV SEOUL INST FOR VIRAL DISEASES

Personal Author(s):

Report Date:

1989-04-01

Pagination or Media Count:

134.0

Abstract:

Studies have confirmed that the epidemic hemorrhagic fever in the peoples Republic of China and the Far Eastern hemorrhagic nephroso-nephritis in the Soviet Union are caused by the same virus and the HFRS in European Russian and the Balkan countries and nephropathia epidemica in Scandinavia are caused by Puumala virus, an antigenically related Bunyavirus that is distinguishable serologically from Hantaan virus. The nephropathia epidemica antigen has been detected and the virus has been isolated from the lungs of the reservoir bank voles Clethrionomys glareolus. In addition, serologic surveys of patients in Sweden, Finland, Hungary, Yugoslavia, and European Russia have shown that both the Hantaan and Puumala serotypes are circulating in these areas. The availability of Hantaan virus antigen has further permitted the diagnosis of urban cases throughout Korea, China, and Japan of a disease, transmitted to man from urban commensal rats Ratus norvegicus and Rattus rattus, which is characterized by mild nephropathy with minimal shock or hemorrhagic diathesis or by only flu-like symptoms with albuminuria. Thus, Hantaan and related viruses cause an acute viral nephropathy across much of the Eurasian landmass in the form of a hemorrhagic disease of great clinical severity. Mortality rates range from 5 to more than 20 in East Asia. Lower mortality rates are found in nephropathia epidemica, a much milder form of non-hemorrhagic nephropathy in Scandinavia.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE