Accession Number:

ADA229126

Title:

Uses of Tyrosine in Foods to Amplify Catecholamine Release

Descriptive Note:

Final technical rept. 30 Mar 1987-29 Mar 1990,

Corporate Author:

MASSACHUSETTS INST OF TECH CAMBRIDGE

Personal Author(s):

Report Date:

1990-11-01

Pagination or Media Count:

6.0

Abstract:

These studies have been part of an ongoing research program on the ability to certain nutrients to affect the production of their neurotransmitter products, and thereby to affect behaviors and other brain functions e.g., control of blood pressure. The studies have focused on the amino acid tyrosine - which is converted, in neurons or chromaffin cells, to dopamine, norepinephrine, and epinephrine. The effect of supplemental tyrosine on brian dopamine release has now been shown directly, using the new technique of in vivo microdialysis. Hemorhage, per se, has been shown to raise neuronal tyrosine levels, probably reflecting a protective mechanism to sustain blood pressure. Adenosine and the amino acid alanine have now also been shown to modulate blood pressure - and adenosine to mediate some of the fall in blood pressure caused by hemorrhage. Various dipeptides diketopiperazines have been shown to enhance dopamine release, either by providing tyrosine or by direct actions. js

Subject Categories:

  • Psychology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE