Accession Number:

ADA229120

Title:

Complex Cognitive Performance and Antihistamine Use

Descriptive Note:

Final rept. 3 Apr 1989-2 Jun 1990,

Corporate Author:

VIRGINIA POLYTECHNIC INST AND STATE UNIV BLACKSBURG

Personal Author(s):

Report Date:

1990-04-01

Pagination or Media Count:

435.0

Abstract:

Research has demonstrated that the majority of antihistamines H1 antagonists have sedative effects and can impair psychomotor performance however, it is claimed that astemizole hismanal does not possess central nervous system side effects. A two-factor, repeated measures, double-blind design was used to compare the effects of three treatments two antihistamines and one placebo on cognitive information processing, mood, selected physiological measures, subjective feelings of drowsiness, and subjective performance rating in 28 healthy men. Evaluations were given at 1,3,5,7,9,11,13 and 15 hours post ingestion. Time-of-day effects were evident in following directions, unstable tracking, code substitution, serial additionsubtraction, logical reasoning, manikin, and pattern comparison tasks. js

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE