Equipment Support Grant for Air Force Task 'Chemical Defense Drugs Effects with Exercise and Thermal Stress'
Final rept. 1 May 1989-30 Apr 1990,
TEXAS UNIV AT EL PASO
Pagination or Media Count:
The effects of a single intramuscular atropine injection 0.03 mgkg at ambient temperatures Ta of 25 C and 35 C and pyridostigmine treatment 5 doses 0.4 mgkg at Ta of 35 C on the thermoregulatory capacity and exercise tolerance time of patas monkeys were investigated. A primate treadmill device was developed and used to evaluate the effects of the drugs on the exercise tolerance time. Rectal temperature Tre and heart rate HR were continuously monitored by a telemetry system while water loss was estimated from weight differences before and after exercise. Atropine effects were more pronounced at Ta of 35 C as indicated by a significant reduction in water loss 43 which was associated with an average exercise time of 65 min less than the control value. The final HR and Tre responses in these atropine experiments were significantly elevated above the control values. Pyridostigmine significantly increased water loss 61 which was associated with an average exercise time of 60 min longer than the control value. js