Accession Number:

ADA229105

Title:

Presynaptic Modulation of the Hippocampal Mossy Fiber Synapse

Descriptive Note:

Annual rept. 15 Sep 1989-14 Sep 1990,

Corporate Author:

EAST CAROLINA UNIV SCHOOL OF MEDICINE GREENVILLE NC

Personal Author(s):

Report Date:

1990-09-14

Pagination or Media Count:

11.0

Abstract:

The overall goal of this research project is to systematically investigate a number of the possible through which presynaptic modulation might influence the effectiveness of local synaptic interactions at the mammalian hippocampal mossy fiber synapse. The potential significance of this research has been dramatically highlighted by the events of this past year, in which several different laboratories conclusively demonstrated that long-term potentiation LTP in the mossy fiber-CA3 synapse involves an enhancement of neurotransmitter release Bekkers et al., 1990 Malinow and Tsien, 1990 Staubli et al., 1990 Zalutsky and Nicoll, 1990. The LTP of synaptic transmission in the hippocampus is a widely studied model system for understanding the cellular mechanisms of memory and synaptic plasticity. Thus, a definitive link has now been established between mossy fiber synaptic plasticity and the presynaptic modulation of this synaptic input. Specifically, any factor that is capable of enhancing or suppressing the release of mossy fiber transmitters will have a predictable effect on the probability that LTP is maintained in the mossy fiber-CA3 synapse. js

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE