Accession Number:

ADA229052

Title:

Nerve Growth Factor Effects on the Immune System

Descriptive Note:

Final rept. Nov 1989-Nov 1990,

Corporate Author:

TEXAS UNIV MEDICAL BRANCH AT GALVESTON

Personal Author(s):

Report Date:

1990-11-15

Pagination or Media Count:

4.0

Abstract:

In the present phase of our study, we have investigated the relationship between the nerve growth factor protein NGF and the hypothalamus- pituitary-adrenocortical axis HPAA, a neuroendocrine system active in the response to stress and the immune system. We found that NGF is not able to stimulate the release of corticosterone from the adrenal glands in rats bearing a pharmacological block of the hypothalamus. Also, this activation of the HPAA can be reduced with anti-NGF. Thus, the stimulatory action of NGF on HPAA requires adrenocorticotropic hormone secretagogues release from the hypothalamus and that NGF modulates HPAA function. js

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE