The Effects of Atropine and Pyridostigmine on Thermoregulation and Work Tolerance in the Patas Monkey
Final rept. May-Sep 1988
TEXAS UNIV AT EL PASO COLL OF SCIENCE
Pagination or Media Count:
The effects of a single intramuscular atropine injection 0.03 mgkg at ambient temperatures Ta of 25 C and 35 C and pyridostigmine treatment 5 DOSES 0.4 MGKG at Ta of 35 C on the thermoregulatory capacity and exercise tolerance time of patas monkeys were investigated. A primate treadmill device was developed and used to evaluate the effects of the drugs on the exercise tolerance time. Rectal temperature Tre and heart rate HR were continuously monitored by a telemetry system while water loss was estimated from weight differences before and after exercise. Atropine effects were more pronounced at Ta of 35 C as indicated by a significant reduction in water loss 43 which was associated with an average exercise time of 65 min less than the control value. The final HR and Tre responses in these atropine experiments were significantly elevated above the control values. Subject Terms Evaporative heat loss Body heat Convective heat loss Chemical defense exercise Oxygen consumption Wet bulb globe temperature Thermoregulation.
- Medicine and Medical Research