Toxicity of Red and Violet Dyes in M18 Grenades: Mutagenic Screening of Three Dyes for Marker Grenades in the Salmonella Reversion Assay and the L5178Y/ TK+/- Mouse Lymphoma Assay
Final rept. Sep 1987-Sep 1988
HEALTH EFFECTS RESEARCH LAB RESEARCH TRIANGLE PARK NC
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Three dyes Solvent Red 1, Disperse Blue 3, and Disperse Red 11 were tested for mutagenicity in the Salmonella reversion assay and the L5178YTK or - mouse lymphoma assay. These in vitro assays were performed both with and without exogenous activation provided by Aroclor induces rat liver S9. In the salmonella assay, Solvent Red 1 was positive with S9 activation in strain TA100 and negative to questionably positive in the other strains and activation to questionably positive under the other test conditions. Disperse Red 11 was positive with S9 activation in strain TA102, but negative to weakly positive with the other strains and activation conditions. Both Disperse Blue 3 and Disperse Red 11 were positive both with and without S9 activation in the mouse lymphoma assay. Solvent Red 1 could not be tested without activation. With S9 activation, it was weakly positive.
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