The Comparison of Gemfibrozil and Lovastatin Therapy in Patients with High LDL and Low HDL Cholesterol Levels
AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH
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Pharmacologic interventions in primary hypercholesteremia are usually considered after saturated fat restricted diet has failed to achieve an adequate control. The specific drug selected may be based, among other things, on its cholesterol lowering efficacy, ability to incidence of coronary heart disease CHD, long term safety record, and cost. In addition, the individual patient lipoprotein profile and the established agents on specific profile components may be considered. Framingham, MRFIT, and epidemiological studies demonstrated that patients with increased low-density lipoprotein LDL cholesterol Clinics Trial showed that lowering elevated levels of LDL cholesterol significantly lowered the risk of CHD development.