Prophylactic and Treatment Drugs for Organophosphorus Poisoning
Annual rept. 30 Sep 1987-29 Sep 1988
ASH STEVENS INC DETROIT MI
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The program is directed at the design and synthesis of treatment and prophylactic drugs as potential defenses against organophosphorus poisoning. During the past year, 11 compounds were submitted one organophosphate organophosphate one physostigmine analog 3-PAM iodide one perfluoroalkyl alkyl hydroxylamine one bispyridinylurea quaternary salt two 1,3,4- oxadiazolones one hydroxyimino-3-methylimidazolium salt one propanesulfonate and one 4,4-biphenylene-bismorpholine. Keywords Organophosphorus poisons, AChE reactivators, Oximes, Hydroxylamines, Carbamates, Synthesis.