Accession Number:

ADA224937

Title:

Inhalation Toxicity of Single Materials and Mixtures

Descriptive Note:

Final rept. 15 Jan 1989-1 Feb 1990

Corporate Author:

IIT RESEARCH INST CHICAGO IL LIFE SCIENCES RESEARCH DIV

Personal Author(s):

Report Date:

1990-02-01

Pagination or Media Count:

102.0

Abstract:

An inhalation exposure generation and monitoring system was develop and tested for exposing laboratory rats to 1 solid particulate aerosols, 2 solid-liquid aerosol mixtures, 3 Cristobalite aerosol positive control and 4 filtered air normal control. The test facility consisted of two laboratories one with five 1 cu.m. inhalation chambers used for exposures to test aerosols, and the second with two chambers for exposure of control rats to filtered air. The aerosol exposure chambers were interfaced with two types of aerosol generators one for the solid particulate aerosols, with liquid aerosols and with solid-liquid aerosol mixtures. Particle size distribution was measured by a Quartz Crystal Microbalance-based cascade impactor. Selected filter samples were analyzed by HPLC to show that neither the aerosol generation process, nor the mixing of solid particulate and PBL aerosols produced any degradation of PBL. Spatial and temporal homogeneity of aerosol concentration and particle size within the chambers were established through a procedure of simultaneous sampling. Statistical analysis of the data demonstrated that the total variation in aerosol concentrations was within the or - 20 limits set for the study at all concentration levels tested.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE