Virulence Markers of Dengue Viruses
Annual rept. (Final) 18 May 1987-18 Aug 1989
CALIFORNIA UNIV BERKELEY
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Illnesses in humans caused by the four serotypes of dengue virus vary from mild forms i. e. pyrexia of unknown origin PUO and dengue fever DF to severe forms i.e. dengue hemorrhagic fever and dengue shock syndrome DHFDSS. One of the factors that contribute to the DHF and DSS disease outcome is proposed to be the variation in the virulence of dengue viruses. We initially evaluated monocyte-infectivity as a marker the for virulence of dengue-2 virus by testing 72 dengue-2 viral isolates associated with PUODF and DHFDSS obtained from eight geographic locations for their ability to infect and multiply in freshly isolated human monocytes. Dengue-2 viral isolates from DHFDSS patients exhibited a higher monocyte-infectivity than that of the isolates from PUO or DF patients. Statistical analyses of the data indicated a correlation between the probability of a dengue-2 viral isolate causing DHFDSS and the viral infection in human monocytes in the presence of dengue enhancing antibodies. Keywords Dengue viruses, Dengue hemorrhagic fever, Virulence, Virulence marker, Monocytes.
- Medicine and Medical Research