Development of Serologic Assays for the Diagnosis of New World Leishmaniasis
Annual rept. 1 Dec 1983-30 Nov 1984
MARYLAND UNIV BALTIMORE SCHOOL OF MEDICINE
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Genus specific monoclonal antibodies have been generated to 14 different isolates of New World Leishmania. These antibodies have been used to identify closely related subspecies to recover genus-specific antigens for the development of sero-diagnostic assays and to identify parasites in infected tissues to quantitate antigen expression on the surface membrane by flow cytometry. Keywords Leishmania Monoclonal antibodies Amastigotes Serodiagnosis Flow cytometry Immunopathology.
- Medicine and Medical Research