Acute Effects of Anticholinesterase Agents on Pupillary Function
Final rept. 15 Jan 1983-14 Jul 1986
SOUTHERN ILLINOIS UNIV SCHOOL OF MEDICINE SPRINGFIELD
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Three main directions of our research has been pursued. New pharmacological evidence is accumulated for a mechanism of ACh release related to a muscarinic autoreceptor present in the rat iris. Secondly, the study of drug effect on release of ACh is continued, adding new groups of drugs. Finally, in the effect of aging on pupillary function and ACh metabolism are studied. These three lines of work have produced novel and intriguing results which are summarized in the enclosed section. The results described in this report have been communicated at several notional and international meetings. The abstracts of the communication are attached to the final report. Keywords Antichloinesterases Pupillary function Vision.