Antibody Responses in the Nonhuman Primate, Macaca Fascicularis, to Protein Toxins
TEXAS UNIV AT SAN ANTONIO
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Bacterial associated protein toxins have been implicated in the pathologic processes in several diseases of man and animals. The bacterium Actinobacillus actinomycetemcomitans produces a protein toxin, leukotoxin, which has been defined by recent research as the primary pathologic factor associated with certain destructive periodontal diseases. Definition of the immunologic relationship between host and protein toxins may serve to identify critical factors in the scheme which might be manipulated for control of the destructive process. The long-range goal of research in this arena is to better understand the immune response to antigenic challenge with protein toxins in man. However, for ethical reasons, some immunopathologic factors cannot be manipulated for appropriate study in man. The nonhuman primate NhP has, in previous investigations, been shown to be more closely immunologically related to man than any othr animal model.