Accession Number:

ADA224451

Title:

One Hundred Eighty Day Subchronic Oral Toxicity Study of Pyridostigmine Bromide in Rats. Volume 2

Descriptive Note:

Rept. for 21 Oct 1986-2 Jun 1987,

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1990-06-01

Pagination or Media Count:

155.0

Abstract:

The 180-day subchronic oral toxicity of pyridostigmine bromide was evaluated in male Sprague-Dawley rats. Pyridostigmine was administered in the diet at dose levels of 0, 1, and 10 mgkgday daily, and 10 mgkgday 5 days per week for 180 days. Following the 180-day dosing period, subgroups of animals from the control, 10 mgkgday, and 10 mgkgday 5 daysweek groups were subjected to a 30-day recovery period during which the test compound was not administered. The addition of pyridostigmine to the diet resulted in dose- related decreases in plasma cholinesterase and erythrocyte acetylcholinesterase activity ranging from 25 to 63 and from 21 to 49, respectively. The only toxic sign associated with the decrease in cholinesterase activity was increased startle reflex which was observed with increased incidence among pyridostigmine- treated animals. Blood samples taken at necropsy for hematological and serum chemistry analyses exhibited no significant abnormalities that could be attributed to pyridostigmine after 180 days of dosing. Increases in aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase were observed at Day 210, 30 days after withdrawal of the test compound, but the changes could not be attributed to compound administrationwithdrawal.

Subject Categories:

  • Biochemistry
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE