Accession Number:

ADA224448

Title:

Ninety-Day Subchronic Oral Toxicity Study of Pyridostigmine Bromide in Rats. Volume 1

Descriptive Note:

Rept. for 21 Oct 1986-12 Mar 1987

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1990-05-01

Pagination or Media Count:

258.0

Abstract:

The 90-day subchronic oral toxicity of pyridostigmine bromide was evaluated in male and female Sprague-Dawley rats. Pyridostigmine was administered in the diet at dose levels of 0, 1, 10, 30, 60, and 90 mgkgday for 90 days. The addition of pyridostigmine to the diet resulted in dose-related decreases in plasma cholinesterase and erythrocyte acetylcholinesterase activity ranging from 5 to 76 and from 18 to 95, respectively. Toxic signs associated with the decrease in cholinesterase activity included muscarinic perianal, perioral, and periocular stains or material, diarrhea, and increased salivation and nicotinic hypertonia and tremors effects. Other signs observed with increased incidence among pyridostigmine-treated animals included irritability, aggression, increased startle reflex, inactivity, jumping, hyperactivity, and chewing. The addition of pyridostigmine to the diet at the 60 and 90 mgkgday dose levels resulted in transient reduction in food and water consumption, and correspondingly reduced weight gains for the first two weeks of the study period.

Subject Categories:

  • Biochemistry
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE