A Circuit Analysis and Computational Model of Operant Conditioning in Aplysia
Annual technical rept. 1 Jul 1989-30 Jun 1990
YALE UNIV NEW HAVEN CT
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Our primary objective is to carry out a cellular and computational analysis of operant conditioning of the headwaving response in Aplysia. Progress has been made in four areas 1 We have now unequivocally identified the neural pathway essential for reinforcement a bilateral set of nerves from the oral veil. 2 We have achieved reliable stimulus control over the operant response headwaving by our discovery that Aplysia shows a strong positive phototaxis to a directional light source. 3 We have identified the neural pathway necessary for phototaxis the nerves from the primary visual organs the eyes and rhinophores. 4 We have preliminary evidence that headwaving motor neurons can be operantly conditioned by direct injection of hyperpolarizing or depolarizing current, paired with reinforcement to increase or decrease their spontaneous firing rate.
- Medicine and Medical Research