Accession Number:

ADA224345

Title:

Natural History of HTLV III Infection in USAF Personnel: Clinical Evaluation, Laboratory Evaluation, Assessment of In Vivo and In Vitro Immunologic Status, and Data Storage

Descriptive Note:

Annual rept.15 Sep 1987-14 Sep 1988

Corporate Author:

WILFORD HALL USAF MEDICAL CENTER LACKLAND AFB TX

Personal Author(s):

Report Date:

1988-12-01

Pagination or Media Count:

12.0

Abstract:

The Wilford Hall USAF Center HIV Scientific Study Group has continued our investigation into the Natural History of HIV disease in active duty USAF personnel and their dependents with intensive immunological evaluation and staging according to the Walter Reed staging classification. Significant progression over 12 months of observation appears to be approximately 10. Studies to determine a marker of disease progression other than absolute CD4a lymphocyte counts are ongoing. Our large neurological natural history study has continued on all active duty HIV-seropositive individuals and they continue to receive full neurological evaluations as well as CSF analysis. Our data demonstrate that the CSF immune response is maximal in early-stage HIV disease and more blunted with respect to both absolute CSF lymphocyte numbers and B-cell immunologic response when CD4a counts drop below 400 cellsmm3. Keywords HTLV IIIHIV Natural history HIV Disease progression USAF Active duty military HIV, HIV Neurological disease RAI Prognostic markers of disease progression. jes

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE