Hepatitis B Virus Infection and Hepatocellular Carcinoma: Correlation Between IgM Antibody to Hepatitis B Core Antigen, Hepatitis B e Antigen, and Hepatitis B DNA
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF COMMUNICABLE DISEASE AND IMMUNOLOGY
Pagination or Media Count:
Sera from 102 black patients with primary hepatocellular carcinoma PHC and hepatitis B surface antigenemia were tested for immunoglobulin M antibody against hepatitis B core IgM anti-HBc, hepatitis B e antigen HBeAg, and hepatitis B viral HBV DNA. Their prevalences were compared to those of a control group of 124 age and sex matched black HBV carriers without tumor. IgM anti-HBc was present in 68.6, HBeAg in 32.3, and HBV-DNA in 26.7 of the patients. In the control population, IgM anti-HBc was present in 45, HBeAg was detected in 3.2, and HBV-DNA in 25.8. We conclude that IgM anti-HBc is present appreciably more often than either HBeAg or HBV-DNA in patients with PHC. HBeAg or IgM anti-HBC in serum of HBsAg positive carriers may predict an added risk of PHC development in South African blacks.
- Medicine and Medical Research