Accession Number:

ADA224204

Title:

Seasonal Fluctuation of Plasmodium falciparum Gametocytaemia

Descriptive Note:

Corporate Author:

ARMED FORCES RESEARCH INST OF MEDICAL SCIENCES APO SAN FRANCISCO 96346

Report Date:

1990-01-01

Pagination or Media Count:

6.0

Abstract:

Plasmodium falciparum is usually first detected in the peripheral circulation of immunologically naive humans as trophozoites 7-11 d after a successful sporozoite inoculation. The number of parasites multiplies exponentially at each 48 h schizogonic cycle, reaching its highest density 5-8 after initial patency. After this asexual peak has subsided, or about 3 weeks after inoculation, gametocytes, which until then have been absent, suddenly flood the circulation. Large numbers of these persist for about 2 weeks, but thereafter they are relatively rare and show no marked periodicity. Since gametocytes are the sexual stage of malaria and propagate only in the mosquito, transmission of the disease is a direct consequence of their availability.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE