Intrinsic Cholinergic Mechanisms Regulating Cerebral Blood Flow as a Target for Organophosphate Action
Annual rept. 30 Sep 1986-29 Sep 1987
CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK
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To investigate acetylcholines AChs role in cardiovascular and cerebrovascular regulation, neuroanatomic substrates were first defined using immunocytochemical mapping from choline acetyltransferase ChAT, the ACh- synthesizing enzyme. ChAT-immunoreactive cell bodies and processes were localized to autonomic or limbic nuclei throughout the neuraxis and close appositions with brainstem microvessels and ependymal cells. Moreover, they codistributed with catecholaminergic neurons staining for tyrosine hydroxylase TH or phenylethanolamine N-methyltransferase PNMT, overlapped structures rich in muscarinic and nicotinic receptors, and expressed autonomic, neuroendocrine or behavioral responsivity to central cholinergic simulation. Keywords Acetylcholine, Choline acetyltransferase, Adrenergic neurons, Central neural pathways.
- Medicine and Medical Research