Effects of Social Conflict on POMC-Derived Peptides and Glucocorticoids in Male Golden Hamsters
Final rept. 1 Aug 1988-1 May 1990
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF NEUROPSYCHIATRY
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The effects of fighting and footshock on circulating adrenocorticotropin, cortisol, corticosterone, beta-endorphin, and beta- lipotropin were examined. In the first experiment, catheterized males were paired with large ovariectomized females for 15 min. Submissive males exhibited significant increases in plasma ACTH, cortisol, corticosterone, and B-EP. In the second experiment, two males were paired to determine whether the hormonal response in submissive animals was different from that in dominant hamsters. The pattern and magnitude of the hormonal response was also compared to that following a commonly used stressor -. Footshock was associated with large increases in each of the plasma hormones measured. Keywords Aggression Agnostic behavior Hamsters Adrenocorticotropin Cortisol Beta-endorphin Stress.