Nonuniform Irradiation of the Canine Intestine. 2. Dosimetry
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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An experimental model has been developed for quantitative studies of radiobiological damage to the canine small intestine following partial-body nonuniformal irradiation. Animals were irradiated with Co gamma rays to simulate the nonuniform irradiation which do occur in victims of radiation accidents. The model used a short source-to-surface distance for unilateral irradiations to produce a dose gradient of a factor of two laterally across the canine intestinal region. The remainder of the animals body was shielded to prevent lethal damage to the bone marrow. In situ dosimetry measurements were made using thermoluminescent dosimeters to determine the radiation dose delivered as a function of position along a segment of the small intestine. This system made it possible to correlate the radiation dose delivered at a specific point along the small intestine with the macroscopic and microscopic appearance of the intestinal mucosa at that point, as determined by direct observation and biopsy using a fiberoptic endoscope.