Antibodies to Liposomes, Phospholipids, and Cholesterol, Implications for Autoimmunity, Atherosclerosis and Aging
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF BIOCHEMISTRY
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It is often stated that lipids are are nonimmunogenic however, this idea is now known to be a false presumption. Polyclonal antibodies having considerable specificity for individual phospholipid constituents of liposomes have now also been developed Wassef et al., 1989 Banerji and Alving, 1989. After developing immunoassay procedures complement-dependent assays and solid- phase immunosorbent assays for detecting antibodies to lipids, we and others discovered that naturally-occurring autoantibodies to various phospholipids are widespread and occur in most adult animal or human sera.