Accession Number:

ADA223638

Title:

Pathophysiology and Toxicokinetic Studies of Blue-Green Algae Intoxication in the Swine Model

Descriptive Note:

Annual rept. 1 Sep 1987-31 Aug 1988

Corporate Author:

ILLINOIS UNIV AT URBANA

Report Date:

1989-09-26

Pagination or Media Count:

160.0

Abstract:

An attempt by New England Nuclear to produce radiolabelled MCLR involved synthetic labelling using tritiated water and RhAl2O3. Chromatography and mass spectrometry revealed radiolabel incorporation into both the toxin and contaminants. The nonspecifically tritiated toxin had a specific activity of 05 uCimg. Subsequently, a method recommended by our laboratory utilizing tritiated water with pyridine was performed by New England Nuclear however, decomposition of the toxin occurred under the conditions used. MCLR was highly bound when added to super-activated charcoal at 1100. When given to rats via an ileal loop shortly after toxin administration, superchar settled out, but was partially effective in limiting MCLR absorption as indicated by increases in liver weight. Keywords Blue-green algae, Phycotoxin, Microcystin, Cyanoginosin anatoxin-as, Pathophysiology, Radiolabelled toxin, Analysis, RA 1, Anatoxin-a.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE