Controlled Release of Antigens for One Dose Immunization
ARMY INST OF DENTAL RESEARCH WASHINGTON DC
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The main objective of this study was to develop a biodegradable, controlled-release adjuvant system capable of eliminating the need for multistep vaccination schedules. This investigation was designed to determine in an animal model hepatitis B vaccine release rate characteristics desirable for single-step immunization, incorporate those release rate characteristics into a one-step biodegradable polyDL-lactide-co-glycolide DL-PLG microencapsulated hepatitis B surface antigen HBsAg vaccine, and conduct an in vivo trial comparing the effectiveness of this single-step vaccine against the conventional three-step hepatitis vaccine currently employed. The results were intended to provide the foundation for further development of single step vaccines against hepatitis and other militarily significant diseases. Keywords Pharmacology, Antigens, One-dose-immunization, Medicine, Vaccines.
- Medicine and Medical Research