Accession Number:

ADA222840

Title:

Neurobehavioral Effects of Carbon Monoxide (CO) Exposure in Humans: Elevated Carboxyhemoglobin (COHb) and Cerebrovascular Responses

Descriptive Note:

Final rept.

Corporate Author:

ENVIRONMENTAL PROTECTION AGENCY RESEARCH TRIANGLE PARK NC

Report Date:

1989-05-19

Pagination or Media Count:

58.0

Abstract:

A two-channel cranial impedance plethysmograph CIP was designed and constructed as a noninvasive measure of brain blood flow BBF in man. The instrument was designed to reduce some of the problems with instability and difficulty of use found in earlier commercially-available models. The CIP has been previously validated against other measures of BBF. During carboxyhemoglobin COHb formation, BBF is known to increase. When BBF increases it compensates for the reduced ability of the blood to carry oxygen in the presence of COHb. Fifteen men breathed carbon monoxide CO to produce increases in COHb values ranging from endogenous 18.4. JES

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE