Resuscitation of Conscious Pigs Following Hemorrhage: Comparative Efficacy of Small-Volume Resuscitation
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
Pagination or Media Count:
Efficacy of small-volume resuscitation 4 mlkg with 7.5 NaCl in 6 Dextran 70 HSD, 7.5 NaCl HS, dextran D, and 0.9 NaCl NS was evaluated in conscious swine bled 37.5 mlkg over 60 min. Hemorrhage reduced cardiac index CI, stroke volume SV, and mean arterial pressure MAP. Four-hour survival after HSD 67 was significantly greater than after HS 25, D 17, or NS 0. The superior performance of HSD, and to a lesser extent HS, was associated with rapid plasma volume expansion, improved CI and SV, and decreased heart rate. The acute increases in cardiac index and stroke volume were greater following treatment with HSD and the improvement persisted for 4 hr. HSD also produced a transient increase in MAP. Plasma Na concentration and osmolality were increased to a similar extent with HSD and HS, while plasma K levels were initially decreased, returning to control levels within 60 min. HSD appears to be a superior small-volume resuscitation solution compared to the other treatments with no detrimental effects. Reprints.
- Medicine and Medical Research