Accession Number:

ADA222674

Title:

Organization and Expression of Plasmodial Genes Required for Erythrocyte Invasion

Descriptive Note:

Annual rept. 1 Aug 1986-31 Jul 1987,

Corporate Author:

SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Personal Author(s):

Report Date:

1988-07-27

Pagination or Media Count:

14.0

Abstract:

The invasion of erythrocytes and sequestration of infected cells in the microvasculature enables P. falciparum to minimize its interaction with the host, resulting, however in the significant morbidity and mortality of falciparum malaria. The molecular basis for parasite sequestration involves a complex macrostructure elicited on the infected erythrocyte surface called the knob. The interaction of parasite and host proteins to form this structure and the genetic regulation of this structure has been investigated through the structural and functional analysis of knob associated proteins. The knob- associated histidine rich protein KAHRP, together with parasite and host derived proteins interact to mediate cytoadherence. Characterization for the protein interactions which result in endothelial cell binding and the identification of parasite proteins involved in this phenotype have been studied through their interaction with the KAHRP. JES

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE