Accession Number:

ADA222647

Title:

Preparation of Potential Radioprotective Agents Derived from Aminothiols

Descriptive Note:

Annual rept. 16 Jul 1985-15 Jul 1986,

Corporate Author:

TEXAS UNIV AT ARLINGTON DEPT OF CHEMISTRY AND BIOCHEMISTRY

Personal Author(s):

Report Date:

1985-09-01

Pagination or Media Count:

45.0

Abstract:

The purpose of this program is to prepare substances containing known and potentially radioprotective fragments bound to small biomolecules. They are to be prepared in small quantities. These compounds are then to be submitted for biological evaluation. The method chosen to link the radioprotective fragment usually an aminothiol to the biomolecule is to join them via a disulfide bond -S-S-. During much of this year particular emphasis has been placed upon the synthesis of potential radioprotective steroids. Two very different methodologies have been used for the synthesis of unsymmetric disulfides. One involves the reaction of a thiol with the thiolsulfinate derived from a different thiol. This method has the potential for producing the desired target compound in high purity with a minimum of side products. During the reporting fifteen 15 compounds were submitted for biological evaluation. Seven of these are steroid-containing substances, two are phenothiazines and three are polymer-bound materials. The latter contain a radioprotective agent e.g., WR- 1065 bound to a polymer by an ionic bond. The polymer which was used was the commercially-available Dowex 50W-X8, an ion-exchange resin containing free sulfonic acid residues. jes

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE