Accession Number:

ADA222511

Title:

Anti-Cyanide Drugs

Descriptive Note:

Annual rept. 1 Apr 1988-31 Mar 1989

Corporate Author:

HOWARD UNIV WASHINGTON DC DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1989-09-01

Pagination or Media Count:

21.0

Abstract:

The purpose of this project was to identify and develop prophylactic anti-cyanide agents including metal complexes, alkylidines, metalloporphyrins and aldehyde and ketone cyanohydrin formers. The screen involved pre- administration of drugs to mice at 15 and 60 minutes, followed by 2 lethal dose- 50s of potassium cyanide. Out of forty-three drugs, only nickel II chloride, cobaltII-chloride and 2-carboxybenzaldehyde survived the screen. The affinity of lower oxidation states of cyanocobaltIIIporphyrins and metalethylenediaminetetraacetic acid adducts for cyanide was probed, and complexes that selectively release a cyanide specific metal upon demand were investigated. Keywords Cyanide, Cyanide scavengers, Porphyrins, Metalloporphyrins, Cobalt, Cyanohydrins, Aldehydes, Ketones, Metal complexes, Nickel.

Subject Categories:

  • Pharmacology
  • Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE