Accession Number:

ADA222475

Title:

In Vitro and In Vivo Measurement of Percutaneous Penetration of Low Molecular Weight Toxins of Military Interest

Descriptive Note:

Annual rept. 22 Dec 1988-22 Dec 1989

Corporate Author:

AUBURN UNIV AL HARRISON SCHOOL OF PHARMACY

Report Date:

1989-12-15

Pagination or Media Count:

112.0

Abstract:

The purpose of this contract is to use an in vitro system to assess the ability of low molecular weight toxins to penetrate through human and guinea pig skin, validate the results obtained in the in vitro system by conducting comparative studies of in vitro and in vivo cutaneous penetration in guinea pigs, assess the effects of specific solvent vehicles on the cutaneous penetration of the low molecular weight toxins, and modify the in vitro experimental system for skin penetration for use in studies of in vitro penetration across mucosal membranes. Toxins to be studied include the brevetoxins, microcystins, lyngbyatoxin A and debromoaplysiatoxin. Progress made during Year 3 of this contract is summarized below. Keywords Skin absorption, Human, Guinea pig, Buccal absorption, Microcystin, Brevetoxin, Lyngbyatoxin A, RA 1, Skinanatomy.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE