Diagnosis of Aids Using Designed Amino Acid Peptides Representing Immunodominant Epitopes of HIV
Rept. for 8 Apr 1988-7 Apr 1989
SCRIPPS CLINIC AND RESEARCH FOUNDATION LA JOLLA CA
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HIV Human Immunodeficiency Virus causes a persistent infection that results in AIDS, Acquired Immune Deficiency Syndrome a major health hazard to military and civilian populations. We have and continue to design and synthesize a variety of amino acid peptides from proteins of HIV-1 and HIV-2 viruses. Our purpose is to map the immunodominant domains of HIV-1 and HIV-2. This information and use of such reagents would accomplish three purposes. First, and under current evaluation, sensitive and specific reagents to diagnosis HIV-1 and HIV-2 infected individuals, define both viruses and mark emerging families of variants would be obtained. Second, the pathogenesis as regards the loss of, or conversely, the evolution of new immune potentially imunopathologic responses could be charted. Third, the data collected would be important for the design of subunit vaccines. Keywords HIV, Immune responses, Diagnosis, Immunopathology, Designed peptides, RA 1.
- Medicine and Medical Research