Accession Number:

ADA222240

Title:

Effects of Protracted Ionizing Radiation Dosage on Humans and Animals: A Brief Review of Selected Investigations

Descriptive Note:

Technical rept. 5 Jun 1984-31 Jan 1985

Corporate Author:

PACIFIC-SIERRA RESEARCH CORP LOS ANGELES CA

Personal Author(s):

Report Date:

1990-06-01

Pagination or Media Count:

68.0

Abstract:

A review of selected investigations of animal irradiation studies, radiation therapy experience, and radiation accident accounts is presented, and some acute effects of protected ionizing radiation exposure on animals and humans are discussed. Various guidelines and models, which account for biological recovery when radiation exposure is protracted over time, are compared. Biological response modifying effects of dose rate and protraction period in humans are discussed in terms of prodromal symptoms. Radiation injury and recovery in a variety of animals, based on the LD50 endpoint, are reviewed and summarized for low and high dose rates ranging from 0.5 to about 700 Rh. Biological recovery models and guidelines are empirical and are primarily based on radiation injury accumulation is animals and gauged by the LD50 endpoint. Further development of appropriate protracted dose models is relevant and necessary for military operations and emergency civil defense planning.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE